Monday, 16 February 2015

Pharmacoeconomics:



More Presentations from Dr.Naina Mohamed Pakkir Maideen

Ø Pharmacoeconomics is a branch of health economics which compares the value of one drug to another.
Ø Pharmacoeconomic analysis involves…
¨   Choosing a perspective
¨   Identifying and measuring costs
¨   Identifying and measuring consequences
Ø Common perspectives include:
¨   Patient perspective
¨   Provider perspective
¨   Payer perspective
¨   Society perspective
Ø Healthcare costs are categorised as…
¨   Direct Medical Costs
¨   Direct Nonmedical Costs
¨   Indirect Nonmedical Costs
¨   Intangible Costs
¨   Opportunity Costs
¨   Incremental Costs
Ø Consequences (Outcomes) are categorised as…
¨   Economic outcomes
¨   Clinical outcomes
¨   Humanistic outcomes
¨   Positive outcomes
¨   Negative outcomes
¨   Intermediate outcome
¨   Final outcome
Ø Pharmacoeconomic methodologies include…
¨   Economic evaluations
·       Partial economic evaluations
o  Cost consequence analysis (CCA) or Cost outcome analysis (COA)
o  Cost-of-illness (COI) evaluation
·       Full economic evaluations
o  Cost Minimization Analysis (CMA)
o  Cost Benefit Analysis (CBA)
o  Cost Effectiveness Analysis (CEA)
o  Cost Utility Analysis (CUA)
¨   Humanistic evaluation
·       Health Regulated Quality of Life (HRQOL)
·       Patient preferences
·       Patient satisfaction
Ø Pharmacoeconomic analysis helps to achieve maximum benefit in limited cost.
Ø Pharmacoeconomic data can be a powerful tool to support various clinical decisions, including effective formulary management, individual patient treatment, medication policy, and resource allocation.
Ø By understanding the principles, methods, and application of pharmacoeconomics, healthcare professionals will be prepared to make better, more-informed decisions regarding the use of pharmaceutical products and services.

Monday, 19 January 2015

Pharmacovigilance:


§  Pharmacovigilance is a scientific discipline concerned with the collection, detection, assessment, monitoring, and prevention of adverse effects of pharmaceutical products.
§  Adverse drug reactions (ADRs) are frequently classified as…
¨  Type A (Augmented) reactions
¨  Type B (Bizarre) reactions
¨  Type C (Chronic) reactions
¨  Type D (Delayed) reactions
¨  Type E (End of use) reactions
§  Pharmacovigilance methodologies include…
¨  Passive drug Surveillance methodologies
o  Spontaneous reports
¨  Active drug surveillance methodologies
o  Enhanced spontaneous reporting
o  Stimulated reporting through solicited reports
o  Designated sentinel sites (sometimes referred to as geographic surveillance)
o  Ad hoc assembly of a cohort of patients
o  Systematic assembly of a cohort of patients
o  Case-controlled surveillance (also called disease registries or disease-specific surveillance)
o  Population-based surveillance
o  Large automated multipurpose databases
§  Most ADRs can be prevented by following the basic principles of rational use of medicines.
§  Pharmacists and Prescribers play important roles in reporting of ADRs.


Monday, 15 December 2014

Pharmacoepidemiology:




More Presentations from Dr.Naina Mohamed Pakkir Maideen

©  Pharmacoepidemiology is the study of effects of drugs in large numbers of people.
©  The word Pharmacoepidemiology is derived from greek words Pharmakon (Drug), Epi (upon), Demos (People) and Logos (Study).
©  Epidemiologic study designs include:
Ø Case reports
Ø Case series
Ø Analyses of secular trends
Ø Case-control study
Ø Cohort study
Ø Randomized clinical trials
©  Pharmacoepidemiologic studies are conducted for:
Ø Regulatory reasons
Ø Marketing reasons
Ø Legal reasons
Ø Clinical reasons
©  Pharmacoepidemiologic studies are used by:
Ø Government agencies & Health care plans
Ø Pharmaceutical industries
Ø Practitioners
Ø Academicians
Ø Attorneys
Ø Consumers and Patients
©  Pharmacists are considered drug experts and naturally they play an important role in Pharmacoepidemiology.
©  Pharmacists and other health care practitioners may serve on Pharmacy Therapeutic Committee, Patient Safety Committees or other groups deciding health care plans.



Monday, 24 November 2014

FDA's warning against “Feng Shi Ling”:




More Presentations from Dr.Naina Mohamed Pakkir Maideen

§  On 20th Nov 2014, the Food and Drug Administration (FDA) is advising consumers not to purchase or use Feng Shi Ling”.
§  Feng Shi Ling” is promoted and sold as an herbal medication for arthritic pain associated with rheumatoid arthritis and osteoporosis.
§  FDA laboratory analysis found that “Feng Shi Ling” contains the undeclared NSAIDs (Diclofenac and Indomethacin).
§  Due to the presence of NSAIDs, “Feng Shi Ling” may increase the risk of …
·      Myocardial infarction
·      Stroke
·      Gastro Intestinal Hemorrhage
·      Gastro Intestinal perforation
·      Bronchoconstriction
·      Rhinosinusitis
·      Acute urticaria
·      Angioedema (skin, lips, and mouth)
·      Allergic reactions (Urticaria, Angioedema or Anaphylaxis)
·      Bleeding
·      Early closure of Ductus arteriosus
·      Renal ischemia (In patients with CHF, CKD, etc)
·      Edema and Hypertensive complications
§  These hidden drug ingredients may interact with other medications such as …
·      Warfarin, Apixaban, Rivaroxaban, Enoxaparin, Dalteparin, Aredeparin, Tinazaparin, Ibritumomab, Tositumomab, Cabozantinib, Ponatinib, Regoratinib, Prasugrel, Anisindione, Fondaparinux or Desirudin
·      Leflunomide, Teriflunomide or Lomitapide
·      Adefovir, Cidofovir, Tenofovir, Tacrolimus, Sirolimus, Sodium Biphosphate or IV Immunoglobulins
·      ACE inhibitors
·      Corticosteroids or SSRIs
§   Consumers should stop using this product immediately and throw it away.
§  Consumers should consult a health care professional as soon as possible if they have experienced any negative side effects, such as unusually dark stools or urine, stomach pain, increased bruising, and other signs of bleeding.


Monday, 22 September 2014

Health benefits of smoking cessation:


More Presentations from Dr.Naina Mohamed Pakkir Maideen
Ø The smokers who quit smoking before the age of 40 live about 10 years longer, on average.

Ø The health of smokers will improve in following ways, when they quit smoking…

·      Better sex

·      Improved fertility

·      Younger looking skin

·      Whiter teeth

·      Better breathing

·      Longer life

·      Less stress

·      Improved smell and taste

·      More energy

·      Healthier loved ones

Ø Stop Smoking and Stay Healthy