Adverse Drug Reactions (ADRs):

More presentations from Naina Mohamed Pakkir Maideen

Ø Unwanted or harmful reaction experienced after the drug administration is termed as “Adverse Drug Reactions (ADRs)”.

Ø Risk Factors for Adverse Drug Reactions (ADRs):

·       Multiple Drug Therapy

·       Age

·       Gender

·       Pregnancy and Breastfeeding

·       Intercurrent disease

·       Drug allergy

Ø Classification of ADRs:

·       Type A (Augmented) reactions

·       Type B (Bizarre) reactions

·       Type C (Chronic) reactions

·       Type D (Delayed) reactions

·       Type E (End-of-use) reactions

Ø Type A (Augmented) reactions:

o  Related to Pharmacological actions of drugs

Ø Type B (Bizarre) reactions:

o  Unrelated to Pharmacological actions of drugs

Ø Type C (Chronic) reactions:

o  Persist for a long time

Ø Type D (Delayed) reactions:

o  Become apparent sometime after the use of a medicine.

Ø Type E (End-of-use) reactions:

o  Associated with the withdrawal of a medicine

Ø “Pharmacovigilance” is the science and activities relating to the detection, education, understanding and prevention of adverse drug reactions or other drug related problems.

Ø Pharmacists and Prescribers play major roles in the reporting of ADRs.