Thursday 24 July 2014
Fluoroquinolones associated “Photogenotoxicity”:
¨ High doses of Fluoroquinolones can bind to DNA directly and cause DNA damage by inhibiting topoisomerase IIα activity.
¨ In presence of Ultraviolet A (UVA) radiation, Fluoroquinolones cause DNA oxidation & topoisomerase IIα inhibition which may lead to DNA damage.
¨ Patients should be warned to avoid exposure to direct sunlight or UV light during treatment and until 36 hours after the discontinuation of treatment, because of the risk of Photogenotoxicity.
¨ Due to severe side effects of Fluoroquinolones, they are not used for regular treatment of bacterial infections.
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